IADR Abstract Archives
Allogenic Block Bone Grafts are as Effective as Autografts
Objectives: Mineralized block allografts (alloblock) are used in dental implantology to increase the base of healthy bone in which to place the implant. This study used a rabbit cortical bone model to examine if there are differences in bone healing and remodeling between an alloblock graft versus the clinical gold standard of autograft.
Methods: Alloblock grafts were 5X1mm cylinders harvested from rabbit femoral cortical bone, cleaned, and stored at -80°C for 1 month; autografts were harvested from the right tibia at time of surgery. Cortical bone defects (5mm) were made in the left femurs of 3.6-4kg male New Zealand White rabbits and implanted with either alloblock (N=7) or autograft (N=7). A 3.2x10mm Ti-6Al-4V grit blasted, acid etched clinical implant (AB Dental, Ashdod, Israel) was implanted in the middle of the grafts. An identical implant was placed in the contralateral femur to serve as a control (N=14). At 10 weeks, micro-CT was used to examine the integration of bone, bone graft, and implant. Results were analyzed by paired t-test (graft versus paired and matched control) or unpaired t-test (alloblock versus autograft).
Results: Bone integration and remodeling were observed on micro-CT in both alloblock and autograft groups. There were no differences in percent bone volume over total volume (BV/TV) between the paired and matched control femurs and allograft-treated femurs. Autograft-treated femurs showed significantly less BV/TV compared to control. No difference was observed between the autograft and alloblock groups.
Conclusions: Compared to paired and matched controls, autografts had significantly less bone, whereas alloblock grafts did not. There was no difference between alloblock and autograft groups. These data indicate that mineralized alloblock cortical grafts may be as effective a bone grafting option as the clinical gold standard of autograft.
Methods: Alloblock grafts were 5X1mm cylinders harvested from rabbit femoral cortical bone, cleaned, and stored at -80°C for 1 month; autografts were harvested from the right tibia at time of surgery. Cortical bone defects (5mm) were made in the left femurs of 3.6-4kg male New Zealand White rabbits and implanted with either alloblock (N=7) or autograft (N=7). A 3.2x10mm Ti-6Al-4V grit blasted, acid etched clinical implant (AB Dental, Ashdod, Israel) was implanted in the middle of the grafts. An identical implant was placed in the contralateral femur to serve as a control (N=14). At 10 weeks, micro-CT was used to examine the integration of bone, bone graft, and implant. Results were analyzed by paired t-test (graft versus paired and matched control) or unpaired t-test (alloblock versus autograft).
Results: Bone integration and remodeling were observed on micro-CT in both alloblock and autograft groups. There were no differences in percent bone volume over total volume (BV/TV) between the paired and matched control femurs and allograft-treated femurs. Autograft-treated femurs showed significantly less BV/TV compared to control. No difference was observed between the autograft and alloblock groups.
Conclusions: Compared to paired and matched controls, autografts had significantly less bone, whereas alloblock grafts did not. There was no difference between alloblock and autograft groups. These data indicate that mineralized alloblock cortical grafts may be as effective a bone grafting option as the clinical gold standard of autograft.