Prevalence of Development Defects of Enamel and Dental Anomalies in Individuals With Mucopolysaccharidosis

Objectives: To identify the prevalence of developmental defects of enamel (DDE) and dental anomalies in individuals with mucopolysaccharidosis (MPS).
Methods: The study comprised 29 individuals with MPS, aged from 3 to 27 years, receiving treatment at two public hospitals in Belo Horizonte in the southeast of Brazil. Subjects underwent an oral exam and DDE and dental anomalies were recorded. The study was approved by the UFMG Ethics Committee. The examiners were calibrated for the clinical exam with kappa values between 0.74 and 0.93. Descriptive analysis of the data was performed.

Results: The mean age of the participants was 13.9 years (+7.3). The majority were male (58.6%), black or mixed race (69.0%), and from a favored economic class (49.3%). The prevalence of DDE was 55.2% [CI 95% (36.0; 74.0)], with the permanent dentition most affected (81.3%). The majority of individuals with MPS (58.6%) were diagnosed with a dental anomaly ([CI 95% (40.0; 78.0)]. The most commonly identified anomaly was rotated teeth (44.8%).

Conclusions: The majority of the individuals with MPS were diagnosed with DDE and/or a dental anomaly. DDE was most prevalent in the permanent dentition, while the most frequently occurring dental anomaly was rotated teeth.