IADR Abstract Archives
Short-term Efficacy Studies of an Occluding Dentifrice on Dentinal Hypersensitivity
Objectives: To investigate efficacy of an experimental anhydrous 0.454% w/w stannous fluoride dentifrice in relieving dentinal hypersensitivity (DH) after a single use and 3 days’ twice-daily brushing, compared with a 0.76% sodium monofluorophosphate marketed control dentifrice.
Methods: Two matched-protocol, single-center, randomized, examiner-blind, stratified, controlled, parallel-design studies in otherwise healthy subjects with DH were performed. Two non-adjacent teeth with DH were selected. Tactile threshold (Yeaple probe) and evaporative air sensitivity (Schiff sensitivity) were assessed (Baseline). Subjects brushed twice-daily (at least 60 seconds); those using the Experimental dentifrice also included an initial focused brushing of test teeth. Schiff sensitivity and tactile threshold were re-assessed post-first use and after 3 days of twice-daily brushing.
Results: Study 1 (N=242): Both dentifrices reduced DH, as assessed by Schiff and tactile threshold, versus baseline after both a single use and after 3 days of twice-daily brushing (all p<0.002). The Experimental dentifrice reduced DH compared to the Control dentifrice for both measures after 3 days’ brushing (both p<0.0001). Study 2 (N=222): The Experimental dentifrice significantly reduced DH, as assessed by Schiff and tactile threshold, compared to baseline after both a single use and after 3 days of twice-daily brushing (p<0.0001). The Control dentifrice had no significant effect on either measure at either time-point. The Experimental dentifrice reduced DH compared to the Control dentifrice for both measures after a single use and after 3 days’ brushing (all p<0.0004). Dentifrices were generally well-tolerated.
Conclusions: In two independent studies, the Experimental 0.454% w/w stannous fluoride-containing dentifrice demonstrated significantly greater reductions in two DH indices after 3 days’ brushing than a marketed control dentifrice, with one study demonstrating a significant difference after a single brushing.
Methods: Two matched-protocol, single-center, randomized, examiner-blind, stratified, controlled, parallel-design studies in otherwise healthy subjects with DH were performed. Two non-adjacent teeth with DH were selected. Tactile threshold (Yeaple probe) and evaporative air sensitivity (Schiff sensitivity) were assessed (Baseline). Subjects brushed twice-daily (at least 60 seconds); those using the Experimental dentifrice also included an initial focused brushing of test teeth. Schiff sensitivity and tactile threshold were re-assessed post-first use and after 3 days of twice-daily brushing.
Results: Study 1 (N=242): Both dentifrices reduced DH, as assessed by Schiff and tactile threshold, versus baseline after both a single use and after 3 days of twice-daily brushing (all p<0.002). The Experimental dentifrice reduced DH compared to the Control dentifrice for both measures after 3 days’ brushing (both p<0.0001). Study 2 (N=222): The Experimental dentifrice significantly reduced DH, as assessed by Schiff and tactile threshold, compared to baseline after both a single use and after 3 days of twice-daily brushing (p<0.0001). The Control dentifrice had no significant effect on either measure at either time-point. The Experimental dentifrice reduced DH compared to the Control dentifrice for both measures after a single use and after 3 days’ brushing (all p<0.0004). Dentifrices were generally well-tolerated.
Conclusions: In two independent studies, the Experimental 0.454% w/w stannous fluoride-containing dentifrice demonstrated significantly greater reductions in two DH indices after 3 days’ brushing than a marketed control dentifrice, with one study demonstrating a significant difference after a single brushing.