The Effect of BMP-2 Delivery in Calcium Phosphate Bone Graft Materials With Different Composition

Objectives: This study aims to investigate the effect of loading rhBMP-2 to BCP and CPP that are calcium phosphate bone graft materials with different compositions on bone regeneration and to examine possible values of BCP and CPP as efficient rhBMP-2 carriers.
Methods: The specimens were divided into the BCP, CPP, BCP/BMP, and CPP/BMP groups. BCP and CPP were in granules and not coated with rhBMP-2. BCP/BMP and CPP/BMP in disc shape were incorporated with rhBMP-2 and collagen. Their physical and biological features were investigated through in-vitro and in-vivo tests.
Results: . Based on histometric measurements, the new bone area percentages (%) of BCP/BMP and CPP/BMP were significantly higher than those of the other groups. At both weeks 4 and 8, CPP/BMP showed the largest new bone area percentage.
Conclusions: Within the limitations of this study, rhBMP-2 coated BCP and CPP presented significant outcome in enhancing bone regeneration. In specific, CPP was verified as a valid carrier of rhBMP-2.