IADR Abstract Archives
BioMin C® - A Smart Fluoride-free Remineralising and Desensitising Toothpaste
Objectives: A novel high phosphate fluoride-free chloride containing bioactive glass was designed and recently introduced into a toothpaste (BioMin C®) for faster remineralisation and desensitisation. The objective of the present in vitro project was to investigate the remineralisation ability of BioMin C® and compare its effect on dentine tubule occlusion qualitatively and quantitatively with commercial Sensodyne Repair and Protect® (SRP®).
Methods: The remineralisation ability of BioMin C® was evaluated in artificial saliva (AS, pH=6.5) up to 2h. X-ray Diffraction and Magic Angle Spinning-Nuclear Magnetic Resonance were used to follow up apatite formation. The ability of the toothpastes to remineralise enamel was assessed by Scanning Micro Radiography (SMR). Dentine tubule occlusion was evaluated qualitatively using Scanning Electron Microscopy (SEM), whereas fluid flow measurements were quantitatively assessed using a Pashley cell.
Results: Rapid calcium and phosphate ions release and apatite formation for BioMin C® was observed within 5 mins of immersion in AS. SMR showed continuous increase in mineral content throughout the treatment period for both toothpastes. However, a higher remineralisation rate was observed for BioMin C®.
SEM images demonstrated a reduction in the number and size of open dentine tubules after treating with BioMin C® and SRP®. Furthermore, unlike SRP®, the specimens treated with BioMin C® did not show a reduction in open tubules number after an acid challenge. The percentage of tubule occlusion increased after a 1h immersion in AS. A dramatic decrease in fluid flow was observed after brushing with both toothpastes. After acid challenge, there was no significate increase in fluid flow with BioMin C® treatment, whereas SRP® showed an increase in fluid flow.
Conclusions: The effective dentine tubule occlusion, fast apatite formation and increasing mineral content which BioMin C® demonstrated would suggest that BioMin C® is an ideal desensitising and remineralising toothpaste.
Methods: The remineralisation ability of BioMin C® was evaluated in artificial saliva (AS, pH=6.5) up to 2h. X-ray Diffraction and Magic Angle Spinning-Nuclear Magnetic Resonance were used to follow up apatite formation. The ability of the toothpastes to remineralise enamel was assessed by Scanning Micro Radiography (SMR). Dentine tubule occlusion was evaluated qualitatively using Scanning Electron Microscopy (SEM), whereas fluid flow measurements were quantitatively assessed using a Pashley cell.
Results: Rapid calcium and phosphate ions release and apatite formation for BioMin C® was observed within 5 mins of immersion in AS. SMR showed continuous increase in mineral content throughout the treatment period for both toothpastes. However, a higher remineralisation rate was observed for BioMin C®.
SEM images demonstrated a reduction in the number and size of open dentine tubules after treating with BioMin C® and SRP®. Furthermore, unlike SRP®, the specimens treated with BioMin C® did not show a reduction in open tubules number after an acid challenge. The percentage of tubule occlusion increased after a 1h immersion in AS. A dramatic decrease in fluid flow was observed after brushing with both toothpastes. After acid challenge, there was no significate increase in fluid flow with BioMin C® treatment, whereas SRP® showed an increase in fluid flow.
Conclusions: The effective dentine tubule occlusion, fast apatite formation and increasing mineral content which BioMin C® demonstrated would suggest that BioMin C® is an ideal desensitising and remineralising toothpaste.