Ion Release of S-PRG Filler Containing Prototype Endodontic Sealer

Objectives: Surface reaction-type pre-reacted glass ionomer filler(S-PRG) has bioactive and antibacterial properties due to its ability to release Fluoride(F), Boron(B), Silicon(Si), and Strontium(Sr). However, few studies have been reported using S-PRG-containing prototype sealer in endodontic procedures. The objective of this pilot study is to measure release of critical ions from S-PRG prototype sealer in vitro over a sustained period of time in comparison to leading commercially available endodontic sealers in the United States.
Methods: Seven extracted human anterior teeth were cleaned and shaped using ProTaper Next(Dentsply-Sirona) rotary file system up to size X3. Teeth were obturated using prototype S-PRG(Shofu), EndoSequence BC(Bio-ceramic)(Brasseler), and ProRoot ES(containing Mineral Trioxide Aggregate)(Dentsply-Sirona) sealers with and without gutta-percha points(GP). Treated teeth were soaked in 1-mL of phosphate buffered saline solution. Ion release over time was measured using an Inductively Coupled Plasma(ICP) mass spectrometer for B, Si,and Sr. One-way ANOVA was used to compare ion release from each of the sealers.
Results: Cumulative ion release over 36 hours is summarized in the table below.
Conclusions: S-PRG sealer released Boron and Strontium ions in higher concentrations (p<0.05) over the same period of time when compared to that of the commercially available sealers. Supported by University of New England Office of Sponsored Research and Shofu Dental Corporation.