Efficacy of ProArgin for Hypersensitivity Relief in MIH Affected Molars

Objectives: The objective of this study was to compare the efficacy in reducing hypersensitivity in MIH affected molars immediately and over 8 weeks combining a single in-office application and an at-home program with desensitizing products containing arginine and calcium carbonate.
Methods: 19 children with at least one MIH affected molar with hypersensitivity were included. Hypersensitivity was assessed with an evaporative (air) stimulus and a tactile stimulus. Each child received a single in-office treatment with elmex Sensitive Professional desensitizing paste containing 8% arginine and calcium carbonate, followed by 8 weeks of brushing twice daily with elmex Sensitive Professional toothpaste with 1450 ppm fluoride, using the elmex Sensitive Professional toothbrush. Additionally, the corresponding mouth wash was used. Clinical assessments were made at baseline, immediately after the in-office treatment and after 1, 2, 4 and 8 weeks of twice daily brushing.
Results: 56 molars with an air blast hypersensitivity score of 2 or 3 (Schiff Cold Air Sensitivity Scale) were included. 16 participants (44 teeth) completed all stages of the study and there were no complaints or reactions associated. Application of the desensitizing paste decreased hypersensitivity significantly immediately and throughout the 8 weeks recalls (p < 0.001). Following scores were evaluated for the airblast test: before treatment: 2.1 +/- 0.3, after treatment: 0.8 +/- 0.8, after 1 week: 1.0 +/- 0.9, after 2 weeks: 0.9 +/- 0.9, after 4 weeks: 0.7 +/ 0.9, after 8 weeks: 0.8 +/- 0.9. The tactile test showed similar results: before treatment: 2.1 +/- 2.6, after treatment: 0.8 +/-1.4, after 1 week: 0.9 +/-1.4, after 2 weeks: 0.7 +/-1.0, after 4 weeks: 0.8 +/-1.4, after 8 weeks: 0.6 +/-1.1.
Conclusions: In conclusion, 8% arginine and calcium carbonate were able to reduce hypersensitivity successfully during this 8 weeks trial.