IADR Abstract Archives
Oral Diseases and the Association With Cognitive Impairment: The MINOPAR Study
Objectives: Objective: The main objective of the MINOPAR (acronym in Swedish meaning Memory and Periodontal Disease) case-control study is to investigate if oral diseases and especially periodontitis are associated with cognitive impairment.
Methods: Methods: This case-control study consist of 150 adult cases suffering from cognitive impairment and 75 healthy age and gender-matched controls. The 150 cases included 50 individuals with Alzheimer disease, 50 with mild cognitive impairment and 50 with subjective cognitive impairment (defined as cognitive complaints with normal cognitive testing), diagnosed at a memory hospital clinic. The study participants undergo a standardized thorough clinical dental examination with focus on periodontal health including a panoramic radiograph as well as an extensive medical examination. Thus, we will collect extensive background data on the study participants with questionnaires and blood samples. From all cases, we will also collect cerebrospinal fluid, bacteria and saliva samples.
Results: Results: All patients and controls have been included, 223 dental examinations performed and blood sampling collected. We recently conducted an unadjusted analysis of the panoramic images to examine differences between the groups using one-way ANOVA. We could not demonstrate statistically significant differences between study groups regarding the variables horizontal alveolar bone loss, number of apical lesions and number of teeth, although a trend towards significance between marginal alveolar bone loss and differences between the groups (p = 0.083) was observed. Tukey post hoc test with pairwise comparisons showed that a the trend was observed between the AD group and the control group (P = 0.083).
Conclusions: Conclusion: The findings suggest that marginal alveolar bone loss, as a sign of periodontal disease, is associated with cognitive impairment. This strengthens the need for further studies regarding the alleged association between the diseases. E-mail: Kare.Buhlin@.ki.se
Supported by: The Swedish Dental Society, funds from Karolinska Institutet and the Stockholm County Council
Methods: Methods: This case-control study consist of 150 adult cases suffering from cognitive impairment and 75 healthy age and gender-matched controls. The 150 cases included 50 individuals with Alzheimer disease, 50 with mild cognitive impairment and 50 with subjective cognitive impairment (defined as cognitive complaints with normal cognitive testing), diagnosed at a memory hospital clinic. The study participants undergo a standardized thorough clinical dental examination with focus on periodontal health including a panoramic radiograph as well as an extensive medical examination. Thus, we will collect extensive background data on the study participants with questionnaires and blood samples. From all cases, we will also collect cerebrospinal fluid, bacteria and saliva samples.
Results: Results: All patients and controls have been included, 223 dental examinations performed and blood sampling collected. We recently conducted an unadjusted analysis of the panoramic images to examine differences between the groups using one-way ANOVA. We could not demonstrate statistically significant differences between study groups regarding the variables horizontal alveolar bone loss, number of apical lesions and number of teeth, although a trend towards significance between marginal alveolar bone loss and differences between the groups (p = 0.083) was observed. Tukey post hoc test with pairwise comparisons showed that a the trend was observed between the AD group and the control group (P = 0.083).
Conclusions: Conclusion: The findings suggest that marginal alveolar bone loss, as a sign of periodontal disease, is associated with cognitive impairment. This strengthens the need for further studies regarding the alleged association between the diseases. E-mail: Kare.Buhlin@.ki.se
Supported by: The Swedish Dental Society, funds from Karolinska Institutet and the Stockholm County Council