IADR Abstract Archives
Application of the Self-assembling Peptide P11-4 on Acid Erosion Prevention
Objectives: The aim of this study was to evaluate the effect of the self-assembling peptide P11-4 on acid erosion prevention by using ultrasound measurement.
Methods: Curodont Repair (CR, Credentis), containing peptide P11-4 was used. Bovine enamel was sliced into a square form (4×4×1 mm). To simulate erosion of teeth, samples were immersed in pure orange juice for 5 min, and repeated 6 times per day for 28 days. These samples were divided into three groups of six specimens each, 1) CR group; specimens were treated with CD without acid challenge, 2) NCRA group ; specimens were immersed in orange juice without CR treatment, 3) CRA group; specimens were treated with a CR before immersion in orange juice. These specimens were stored in artificial saliva during the experimental period. Longitudinal ultrasound velocity (UV) was measured. Two-way ANOVA and Tukey’s post hoc test were used for statistical analysis.
Results: The average UV of NCRA group decreased during time period. On the other hand, increased UVs were found for CR and CRA groups. The average values for UV (m/s) are shown in the table below.
Conclusions: It can be concluded that the CR treatment was effective in preventing enamel demineralization, and might have the ability to enhance enamel remineralization.
Methods: Curodont Repair (CR, Credentis), containing peptide P11-4 was used. Bovine enamel was sliced into a square form (4×4×1 mm). To simulate erosion of teeth, samples were immersed in pure orange juice for 5 min, and repeated 6 times per day for 28 days. These samples were divided into three groups of six specimens each, 1) CR group; specimens were treated with CD without acid challenge, 2) NCRA group ; specimens were immersed in orange juice without CR treatment, 3) CRA group; specimens were treated with a CR before immersion in orange juice. These specimens were stored in artificial saliva during the experimental period. Longitudinal ultrasound velocity (UV) was measured. Two-way ANOVA and Tukey’s post hoc test were used for statistical analysis.
Results: The average UV of NCRA group decreased during time period. On the other hand, increased UVs were found for CR and CRA groups. The average values for UV (m/s) are shown in the table below.
Conclusions: It can be concluded that the CR treatment was effective in preventing enamel demineralization, and might have the ability to enhance enamel remineralization.