Examine the Application of Nanotechnology in Oral Cancer

Objectives: [Objectives]
The surface of TiO₂ (titanium di oxide) photo catalyst has been shown to have high activity for the decomposing organic compounds and has been used as anti-bacterial and self-cleaning material.
We have been studying the possibility for therapeutic application of TiO₂ photo catalysis in medical field.
This study examined potency of application of TiO₂ malignant tumor in oral cavity. We mixed the photocatalyst titanium di oxide powder (TiO₂) coated on gold particles and the anticancer drug (Adriamycin) and introduced this mixture into the oral mucosa and oral tumor by using Gene Gun (Helios Gene Gun). And we observed the reaction in oral mucosa and the surrounding tissues.
Methods: [Methods]
50mg gold particles (φ1μm) electrostatically coated with TiO₂ is mixed with 0.8mg Adriamycin. This mixture was capsulated into a plastic bullet for Gene Gun. The bullet was injected into the oral mucosa and oral tumor using a Gene Gun. Experiment of three groups was conducted as follows:
1. Group UV (+): The affected area were treated with the TiO_2-ADM mixture and irradiated with UV (358nm, 2.0mw/cm² .30min) light.
2. Group UV (-): The affected area was heated with the TiO_2-ADM mixture and was not irradiated with UV light.
3. Control group: No treatment .
The light irradiation group and the non-irradiated group were compared.
After introduction of TiO_2-ADM mixture, the change of affected area was observed macroscopically and histologically.
Results: [Results and Conclusion]
The results of this study show that UV light radiation is effective for reducing side effects when applying the combination of TiO₂ and the anticancer drug (Adriamycin) to oral cancer treatment. In the future, more study is needed to evaluate the effectiveness of TiO₂ photocatalysis and anticancer drug for cancer treatment.
Conclusions: [Results and Conclusion]
The results of this study show that UV light radiation is effective for reducing side effects when applying the combination of TiO₂ and the anticancer drug (Adriamycin) to oral cancer treatment. In the future, more study is needed to evaluate the effectiveness of TiO₂ photocatalysis and anticancer drug for cancer treatment.