IADR Abstract Archives

Sclerostin Antibody Enhances the Alveolar Bone Regeneration Surrounding Dental Implants

Objectives: Background: Dental implants are an important option for replacing lost teeth. A major clinical goal is to accelerate bone healing times for functional restoration after implant placement. Antibody against Sclerostin (Scl-Ab) has been shown to enhance bone formation and bone fracture repair.
Aim: To investigate the effects of Scl-Ab on bone regeneration and dental implant osseointegration in an experimental alveolar bone defect model.
Methods: one month after maxillary first molar extraction in rats, a “well type” osteotomy was created at the extraction site, and a 1x2 mm dental titanium implant was placed into the osteotomy site. Following the first day of implant placement, Scl-Ab (25 mg/kg) was administrated systemically by twice-weekly SC injections. PBS was injected as a vehicle control. Ten and 14 days after surgery, the maxillae were harvested, fixed by 10% formalin, scanned and analyzed by microCT. After microCT scanning, the maxillae were embedded in resin, sectioned and stained with methylene blue and acid fuchsin for descriptive histology and histomorphometry.
Results: MicroCT analysis demonstrated that bone volume fraction was approximately 2-fold greater in Scl-Ab treatment groups compared to vehicle alone at day 14. Bone fill percentage and bone-implant contact percentage were not different between two groups at day 10 and day 14.
Conclusions: Scl-Ab enhanced bone regeneration around dental implants in alveolar bone defects. This treatment approach offers potential to help accelerate bone healing around dental implant sites placed simultaneously into bony defects. Supported by the Osteology Foundation.
IADR/AADR/CADR General Session
2017 IADR/AADR/CADR General Session (San Francisco, California)
San Francisco, California
2017
3553
  • Jin Qiming  ( University of Michigan, School of Dnetistry , Ann Arbor Ann Arbor , Michigan , United States )
  • Yu Shan Huey  ( University of Michigan, School of Dentistry , Ann Arbor Ann Arbor , Michigan , United States )
  • Hao Jie  ( University of Michigan, School of Dentistry , Ann Arbor Ann Arbor , Michigan , United States )
  • Fretwurst Tobias  ( University of Michigan, School of Dentistry , Ann Arbor Ann Arbor , Michigan , United States )
  • Ominsky Mike  ( Amgen Inc. , Thousand Oaks Thousand Oaks , California , United States )
  • Liu Min  ( Amgen Inc. , Thousand Oaks Thousand Oaks , California , United States )
  • Kostenuik Paul  ( Amgen Inc. , Thousand Oaks Thousand Oaks , California , United States )
  • Giannobile William  ( University of Michigan, School of Dentistry , Ann Arbor Ann Arbor , Michigan , United States ;  University of Michigan, College of Engineering , Ann Arbor Ann Arbor , Michigan , United States )
  • Osteology Foundation #14-040
    None
    Poster Session
    Physiological and Biomechanical Effects in Oral Rehabilitation
    Saturday, 03/25/2017 , 11:00AM - 12:15PM