IADR Abstract Archives
The Influence of Ancestry in Dental Development: A Geographic and Genetic Perspective
Objectives: We aimed to estimate the ethnic diffrences in dental development within a multi-ethnic population-based prospective cohort study in the city of Rotterdam, the Netherlands. We further explored to what extent the geographically based ethnicicty and genetically based ethnicity could explain these differences.
Methods: This study was performed in the Generation R Study, a multi-ethnic population-based prospective cohort study. Information about geographically based ethnicity was available in 3600 children (1810 boys and 1790 girls) with a mean age of 9.81 years (SD; 0.35) and information about genetically based ethnicity was available in 2349 children (1184 boys and 1165 girls) with a mean age of 9.82 (SD; 0.35). Dental development was assessed for all the children using the Demirjian method. The association between geographic based ethnicity and dental development was analyzed using two linear regression models. This analysis was repeatedly performed for each non-Dutch ethnicity (Cape Verdean, Moroccan, Turkish, Dutch Antillean, Surinamese Creole and Surinamese Hindustani) vs Dutch ethnicity. The same analysis and models were applied to study the association between genetic based ethnicity (European origin vs non-European origin) and dental age.
Results: Moroccan (β, 0.12; 95%CI: 0.02, 0.22), Turkish (β, 0.12; 95%CI: 0.03, 0.22), Dutch Antillean (β, 0.25; 95%CI: 0.11, 0.39) and Surinamese Creole (β, 0.17; 95%CI: 0.04, 0.31) exceeded Dutch children in dental development. Moreover, genetically specified non-European children (β, 0.13; 95%CI: 0.07, 0.20) exceeded European children in dental development. This advance was explained by a faster calcification corresponding to 0.2-0.5 developmental stages for the lateral incisor, canine, first premolar, second premolar, first molar and second molar.
Conclusions: Differences in dental development exist in a heterogeneous population and should be considered when deciding the right clinical timing of orthodontic treatment and in dental research.
Methods: This study was performed in the Generation R Study, a multi-ethnic population-based prospective cohort study. Information about geographically based ethnicity was available in 3600 children (1810 boys and 1790 girls) with a mean age of 9.81 years (SD; 0.35) and information about genetically based ethnicity was available in 2349 children (1184 boys and 1165 girls) with a mean age of 9.82 (SD; 0.35). Dental development was assessed for all the children using the Demirjian method. The association between geographic based ethnicity and dental development was analyzed using two linear regression models. This analysis was repeatedly performed for each non-Dutch ethnicity (Cape Verdean, Moroccan, Turkish, Dutch Antillean, Surinamese Creole and Surinamese Hindustani) vs Dutch ethnicity. The same analysis and models were applied to study the association between genetic based ethnicity (European origin vs non-European origin) and dental age.
Results: Moroccan (β, 0.12; 95%CI: 0.02, 0.22), Turkish (β, 0.12; 95%CI: 0.03, 0.22), Dutch Antillean (β, 0.25; 95%CI: 0.11, 0.39) and Surinamese Creole (β, 0.17; 95%CI: 0.04, 0.31) exceeded Dutch children in dental development. Moreover, genetically specified non-European children (β, 0.13; 95%CI: 0.07, 0.20) exceeded European children in dental development. This advance was explained by a faster calcification corresponding to 0.2-0.5 developmental stages for the lateral incisor, canine, first premolar, second premolar, first molar and second molar.
Conclusions: Differences in dental development exist in a heterogeneous population and should be considered when deciding the right clinical timing of orthodontic treatment and in dental research.