IADR Abstract Archives
Effects of Fluoride Concentration and Treatment Time on Lesion De-/Remineralization
Objectives: The aim was to determine the effects of fluoride treatment time and concentration on caries lesion de-/remineralization and fluoridation under pH cycling conditions.
Methods: The study design was based on a 3 (fluoride concentration: 0; 275; 1250ppm as sodium fluoride solutions) × 4 (treatment time: 10; 30; 60; 120s) factorial design (12 groups in total). Early caries lesions were created in polished bovine enamel specimens (n=18 per group) and pH cycled for 18d as per table 1.
Lesions were analyzed using Vickers surface microhardness before and after the pH cycling phase and the change in hardness was calculated (ΔVHN). Enamel fluoride uptake (EFU) was determined using the microbiopsy technique. Data were analyzed using two-way ANOVA (p<0.05).
Results: The concentration×treatment time interaction was significant for both ΔVHN (p<0.0001) and EFU (p=0.0298). Dose-response relationships were observed for both variables for fluoride concentration and treatment time. Tables 2 and 3 show means±standard deviations and the results of the statistical analysis.
Conclusions: Increasing fluoride exposure time will enhance fluoride’s anticaries efficacy. Increasing fluoride concentrations may potentially compensate for shorter exposure times.
Methods: The study design was based on a 3 (fluoride concentration: 0; 275; 1250ppm as sodium fluoride solutions) × 4 (treatment time: 10; 30; 60; 120s) factorial design (12 groups in total). Early caries lesions were created in polished bovine enamel specimens (n=18 per group) and pH cycled for 18d as per table 1.
Lesions were analyzed using Vickers surface microhardness before and after the pH cycling phase and the change in hardness was calculated (ΔVHN). Enamel fluoride uptake (EFU) was determined using the microbiopsy technique. Data were analyzed using two-way ANOVA (p<0.05).
Results: The concentration×treatment time interaction was significant for both ΔVHN (p<0.0001) and EFU (p=0.0298). Dose-response relationships were observed for both variables for fluoride concentration and treatment time. Tables 2 and 3 show means±standard deviations and the results of the statistical analysis.
Conclusions: Increasing fluoride exposure time will enhance fluoride’s anticaries efficacy. Increasing fluoride concentrations may potentially compensate for shorter exposure times.