IADR Abstract Archives
Potentiality of Salivary Lysozyme and Uric Acid as Periodontitis Markers
Objectives: This study aims to evaluate the association of salivary lysozyme and uric acid with periodontitis.
Methods: Lysozyme and uric acid from 538 and 499 participants in Yangpyeong cohort were analyzed for the association with periodontitis. Unstimulated saliva was collected and salivary lysozyme and uric acid were analyzed by enzyme-linked immunosorbent assay. Both lysozyme and uric acid were categorized into three groups by tirtile values; low (<1.10), medium (1.10 to <5.86) and high (≥5.86ng/ml) for lysozyme and low (<161.91), medium (161.91 to <259.57) and high (≥259.57nmol/ml) for uric acid. For normal distribution, the data of lysozyme and uric acid were transformed. Alveolar bone loss was evaluated by panoramic X-ray. Periodontitis was classified into normal, moderate and severe periodontitis according to CDC-AAP guideline. Age, sex, education, smoking, drinking, exercise and metabolic syndrome were considered as confounders. ANCOVA and logistic regression analysis were performed to evaluate the adjusted association of lysozyme and uric acid with periodontitis. Moderate and severe periodontitis were considered as periodontitis for logistic regression analysis. Stratified analyzes by age group and sex were performed.
Results: Increased level of lysozyme showed association with periodontitis (ANCOVA, p=0.027),while uric acid was not associated. The estimated means of real value of lysozyme were 2.12, 3.04 and 3.29 ng/ml for normal, moderate and severe periodontitis, respectively. High level of lysozyme compared to low level was associated with periodontitis after controlling for confounders (odds ratio =1.80; 95% confidence interval of 1.16-2.81). The association was highlighted in females and those aged less than 65 years.
Conclusions: The association was highlighted in females and those aged less than 65 years. Our data showed that salivary lysozyme was associated with periodontitis. Hence, lysozyme in saliva could be a potential marker for periodontitis.
Methods: Lysozyme and uric acid from 538 and 499 participants in Yangpyeong cohort were analyzed for the association with periodontitis. Unstimulated saliva was collected and salivary lysozyme and uric acid were analyzed by enzyme-linked immunosorbent assay. Both lysozyme and uric acid were categorized into three groups by tirtile values; low (<1.10), medium (1.10 to <5.86) and high (≥5.86ng/ml) for lysozyme and low (<161.91), medium (161.91 to <259.57) and high (≥259.57nmol/ml) for uric acid. For normal distribution, the data of lysozyme and uric acid were transformed. Alveolar bone loss was evaluated by panoramic X-ray. Periodontitis was classified into normal, moderate and severe periodontitis according to CDC-AAP guideline. Age, sex, education, smoking, drinking, exercise and metabolic syndrome were considered as confounders. ANCOVA and logistic regression analysis were performed to evaluate the adjusted association of lysozyme and uric acid with periodontitis. Moderate and severe periodontitis were considered as periodontitis for logistic regression analysis. Stratified analyzes by age group and sex were performed.
Results: Increased level of lysozyme showed association with periodontitis (ANCOVA, p=0.027),while uric acid was not associated. The estimated means of real value of lysozyme were 2.12, 3.04 and 3.29 ng/ml for normal, moderate and severe periodontitis, respectively. High level of lysozyme compared to low level was associated with periodontitis after controlling for confounders (odds ratio =1.80; 95% confidence interval of 1.16-2.81). The association was highlighted in females and those aged less than 65 years.
Conclusions: The association was highlighted in females and those aged less than 65 years. Our data showed that salivary lysozyme was associated with periodontitis. Hence, lysozyme in saliva could be a potential marker for periodontitis.