IADR Abstract Archives
Strontium-coated Deproteinized Bovine Bone Grafting Enhances Bone Repair in Calvarial Critical Size Defects
Objectives: To evaluate the effect of strontium (Sr) coated deproteinized bovine bone (DBB-Sr) grafting on bone healing of calvarial critical-size defects (CSD) in rats.
Methods: Forty-two female rats were randomly divided into 3 groups of 14 animals each. Two CSD, 5mm in diameter, were created in the parietal bones and one defect was grafted either with DBB, or DBB-Sr1 (140μM per g OBD) or DBB-Sr2 (700μM per g OBD); the other defect remained empty as control. The amount of mineralized tissue into the CSD was evaluated by micro CT 7 and 14 days post-operatively (7 animals pr. group). One-way Anova complemented by Tukey test at the confidence level of 95% was used for the statistical analysis.
Results: DBB-Sr2 presented a smaller length of residual CSD comparing to defects filled with DBB-Sr1 at 15 days (p <0.05) and to defects filled with DBB (p <0.05) or DBB-Sr1 (p <0.001) at 60 days. Further, DBB-Sr2 showed greater amount of mineralized tissue fill compered to defects implanted with DBB at 15 days (p<0.01) and to defects implanted with DBB (p<0.001) or DBB-Sr1 (p<0.001) at 60 days.
Conclusions: Sr coating of DBB improved bone repair in critical-size calvarial defects in rats.
Methods: Forty-two female rats were randomly divided into 3 groups of 14 animals each. Two CSD, 5mm in diameter, were created in the parietal bones and one defect was grafted either with DBB, or DBB-Sr1 (140μM per g OBD) or DBB-Sr2 (700μM per g OBD); the other defect remained empty as control. The amount of mineralized tissue into the CSD was evaluated by micro CT 7 and 14 days post-operatively (7 animals pr. group). One-way Anova complemented by Tukey test at the confidence level of 95% was used for the statistical analysis.
Results: DBB-Sr2 presented a smaller length of residual CSD comparing to defects filled with DBB-Sr1 at 15 days (p <0.05) and to defects filled with DBB (p <0.05) or DBB-Sr1 (p <0.001) at 60 days. Further, DBB-Sr2 showed greater amount of mineralized tissue fill compered to defects implanted with DBB at 15 days (p<0.01) and to defects implanted with DBB (p<0.001) or DBB-Sr1 (p<0.001) at 60 days.
Conclusions: Sr coating of DBB improved bone repair in critical-size calvarial defects in rats.