IADR Abstract Archives
Osseointegration of Surface Modified Titanium and Titanium Zirconium Implants in an Osteoporotic Sheep Model
Objectives: To investigate the effect of topographical and chemical modification of dental implants on osseointegration in a sheep model of osteoporosis.
Methods: 18 adult female Corriedale sheep were used. 9 sheep were subject to a hypothalamus pituitary disconnection procedure to induce osteoporosis, and the remaining 9 sheep were non-operated controls. After 15 months, Titanium SLA (T-SLA), Titanium SLActive (T-modSLA) and Titanium Zirconium Alloy SLActive (TZ-modSLA) implants were randomly inserted in the mandible bilaterally. The animals were sacrificed after 2, 4 and 6 weeks. Histomorphometry of resin embedded samples was used to compare percentage Bone to Implant Contact (BIC) and Bone Area (BA) around the implants.
Results: At 2 weeks, BIC was significantly higher for control compared to osteoporotic groups for T SLA and T-modSLA implants. No difference was found at the 4 and 6 week time points. TZ-modSLA implants had similar BIC to T-modSLA implants at 2, 4 and 6 weeks in both control and osteoporotic groups. SLA implants had reduced BIC at 2 and 4 weeks compared to T-modSLA and TZ-modSLA implants.
In the control groups, BIC reached close to peak levels at 2 weeks with no further increase in BIC at 4 and 6 weeks. There was higher BIC at 6 weeks compared to 2 weeks in the osteoporotic group for all three implant types.
BA increased over time for osteoporotic T-SLA, T-modSLA and TZ-modSLA groups and control T-SLA and T-modSLA groups. T-SLA implants had reduced BA at 2 weeks compared to T-modSLA and TZ-modSLA implants. T-modSLA and TZ-modSLA implants had no difference in BA at 2, 4 and 6 weeks.
Conclusions: BIC was higher in the control compared to the osteoporotic group at 2 weeks. BA increased over time for both osteoporotic and control groups. TZ-modSLA implants performed similarly to T-modSLA implants for BIC and BA. T-SLA implants had less BIC and BA at 2 weeks compared to the T-modSLA and TZ-modSLA implants.
Methods: 18 adult female Corriedale sheep were used. 9 sheep were subject to a hypothalamus pituitary disconnection procedure to induce osteoporosis, and the remaining 9 sheep were non-operated controls. After 15 months, Titanium SLA (T-SLA), Titanium SLActive (T-modSLA) and Titanium Zirconium Alloy SLActive (TZ-modSLA) implants were randomly inserted in the mandible bilaterally. The animals were sacrificed after 2, 4 and 6 weeks. Histomorphometry of resin embedded samples was used to compare percentage Bone to Implant Contact (BIC) and Bone Area (BA) around the implants.
Results: At 2 weeks, BIC was significantly higher for control compared to osteoporotic groups for T SLA and T-modSLA implants. No difference was found at the 4 and 6 week time points. TZ-modSLA implants had similar BIC to T-modSLA implants at 2, 4 and 6 weeks in both control and osteoporotic groups. SLA implants had reduced BIC at 2 and 4 weeks compared to T-modSLA and TZ-modSLA implants.
In the control groups, BIC reached close to peak levels at 2 weeks with no further increase in BIC at 4 and 6 weeks. There was higher BIC at 6 weeks compared to 2 weeks in the osteoporotic group for all three implant types.
BA increased over time for osteoporotic T-SLA, T-modSLA and TZ-modSLA groups and control T-SLA and T-modSLA groups. T-SLA implants had reduced BA at 2 weeks compared to T-modSLA and TZ-modSLA implants. T-modSLA and TZ-modSLA implants had no difference in BA at 2, 4 and 6 weeks.
Conclusions: BIC was higher in the control compared to the osteoporotic group at 2 weeks. BA increased over time for both osteoporotic and control groups. TZ-modSLA implants performed similarly to T-modSLA implants for BIC and BA. T-SLA implants had less BIC and BA at 2 weeks compared to the T-modSLA and TZ-modSLA implants.