IADR Abstract Archives
The Antimicrobial Effect of Sodium Hypochlorite Agents for Intraoral Use
Objectives: Different strategies have during the years been used in order to reduce the risk for dental caries and periodontitis. These include the use of antimicrobial agents. The aim of this study was to compare the effect of two sodium hypochlorite-containing agents (Carisolv™ and Perisolv™) to other well-known antimicrobial agents.
Methods: The following eight substances were compared regarding their minimal inhibitory concentration (MIC) after 5 and 10 min using agar diffusion test and minimum bactericidal concentration (BMC): Perisolv gel, Carisolv gel, Perisolv liquid, NaOCl (component of Perisolv), Amino acids (component of Perisolv), Dakin´s solution, H2O2, and Chlorhexidine. The agents were tested against ten different oral microorganisms related to dental caries or periodontitis in one and the same concentration (0.5%) and in their regular concentration.
Results: All irrigants, except for H2O2 and the pure amino acids, did for MIC show a clear antimicrobial effect. The strongest effect was found for chlorhexidine. A similar effect of the chloramines in the different formulas was found when tested as the Perisolv gel, Perisolv liquid and the Carisolv gel (all 0.5%). Only minor differences were found when comparing the effect of the ten bacterial strains. Analyses by the BMC showed that lower amount was needed for the Perisolv (30.5 μg/ml; agent/bacteria) than for Carisolv (47.5 μg/ml; agent/bacteria). The antimicrobial effect against tested microorganisms was more pronounced when using Perisolv compared to chlorhexidine. Two-way factorial ANOVA showed a statistically significant effect when comparing the different agents (p<0.01). A more pronounced effect for tested microorganisms was also seen after the 10 min exposure time compared to 5 min.
Conclusions: The two sodium hypochlorite-containing agents (Carisolv™ and Perisolv™) tested showed a clear antimicrobial effect against caries- respectively periodontal-related microorganisms.
Methods: The following eight substances were compared regarding their minimal inhibitory concentration (MIC) after 5 and 10 min using agar diffusion test and minimum bactericidal concentration (BMC): Perisolv gel, Carisolv gel, Perisolv liquid, NaOCl (component of Perisolv), Amino acids (component of Perisolv), Dakin´s solution, H2O2, and Chlorhexidine. The agents were tested against ten different oral microorganisms related to dental caries or periodontitis in one and the same concentration (0.5%) and in their regular concentration.
Results: All irrigants, except for H2O2 and the pure amino acids, did for MIC show a clear antimicrobial effect. The strongest effect was found for chlorhexidine. A similar effect of the chloramines in the different formulas was found when tested as the Perisolv gel, Perisolv liquid and the Carisolv gel (all 0.5%). Only minor differences were found when comparing the effect of the ten bacterial strains. Analyses by the BMC showed that lower amount was needed for the Perisolv (30.5 μg/ml; agent/bacteria) than for Carisolv (47.5 μg/ml; agent/bacteria). The antimicrobial effect against tested microorganisms was more pronounced when using Perisolv compared to chlorhexidine. Two-way factorial ANOVA showed a statistically significant effect when comparing the different agents (p<0.01). A more pronounced effect for tested microorganisms was also seen after the 10 min exposure time compared to 5 min.
Conclusions: The two sodium hypochlorite-containing agents (Carisolv™ and Perisolv™) tested showed a clear antimicrobial effect against caries- respectively periodontal-related microorganisms.