Salivary Fluoride Concentrations Using Four Different Types of Fluoridated Dentifrices

Objectives: Objectives: This crossover study was carried out to evaluate salivary fluoride retention following tooth brushing using different fluoridated dentifrices containing surface reaction-type prereacted glass-ionomer filler (S-PRG), amine fluoride (AmF), sodium fluoride (NaF), and sodium monofluoriphosphate (MFP), respectively.
Methods: Method: Eight consenting adult subjects brushed their teeth in the same manner using dentifrices (0.5g) containing S-PRG, 1500ppm fluoride containing NaF and MFP, and 1400ppm AmF dentifrices, respectively. Following tooth brushing for 2 minutes, they spat out once and rinsed their mouths with 15ml of distilled water for 5 seconds. Saliva samples were collected for 3 minutes each at different time intervals; 5, 10, 15, 30, 60, 120 and 180 minutes following rinsing. Pre-brushing saliva samples served as control. One-tenth volumes of low-level TISAB were added into the saliva samples and then fluoride concentrations were determined using a fluoride ion-specific electrode. We compared the four different types of fluoridated dentifrices, in regard to salivary fluoride concentrations in each subject. The area under the curve (AUC) of fluoride was calculated using a graph on which the horizontal base line represents sampling time and the vertical scale represents fluoride concentration. Non-parametric tests were used to conduct multiple comparisons of salivary fluoride concentrations after each time interval and the AUC among the dentifrices.
Results: Results: Statistical differences (p<0.01) were shown in the fluoride concentrations (ppm, mean±SD) for each time interval. MFP dentifrices displayed the lowest fluoride levels, whereas AmF appeared to result in higher salivary fluoride levels during the whole experimental period. SPR-G showed similar levels as AmF.
The AUC (µm･min, mean±SD) for the 180 minutes showed statistical differences between AmF (100.9±102.2) and MFP (24.6±8.5), S-PRG (92.3±83.7) and NaF (49.5±26.4) (p<0.01) , as well as AmF and NaF (p<0.05).
Conclusions: Conclusion: These results suggest that AmF and S-PRG dentifrices have higher salivary fluoride retention levels.