IADR Abstract Archives
Preemptive Effect of Etoricoxib Versus Ibuprofen in Third Molar Surgery
Objectives: The present study aimed to investigate the preemptive analgesic efficacy and anti-inflammatory effect of ibuprofen and etoricoxib in mandibular third molar surgery, compared with placebo.
Methods: The study design consisted of a randomized, double-blind, placebo-controlled crossover trial conducted with patients undergoing surgical removal of mandibular third molars with similar pattern of bone inclusion and surgical difficulty between right and left sides, requiring bone removal under local anesthesia. Eighteen eligible patients were allocated into three groups to receive a single dose of ibuprofen 400mg, etoricoxib 120mg, or placebo, 1-hour preoperatively. Pain intensity, use of analgesic rescue medication, swelling and trismus were evaluated. Pain intensity was recorded at 0, 2, 4, 6, 8, 10, 12, 24, 48, 72 h, 5 and 7 days following surgery. Swelling and trismus was recorded at 24, 72 h, 5 and 7 days following surgery. Parametric data was analyzed with ANOVA/Bonferroni test. The non-parametric data was analyzed with Kruskall-Wallis/Dunn or Friedman/Dunn tests. Rescue medication consumption was evaluated with Kaplan-Meyer plot. Significance level was set at p£0.05.
Results: Ibuprofen and etoricoxib reduced the pain scores in relation to placebo (p<0.0001), and etoricoxib reduced pain scores significantly in comparison with ibuprofen (p<0.05). The mean of rescue medication consumed was different between ibuprofen (1.7±2.0), etoricoxib (0.8±06), and placebo (1.0±2.7) groups over the study period (p=0.0052), and was significantly lower in the etoricoxib group in comparison with the placebo group (p<0.05). There was no statistically significant differences between groups related to swelling and trismus.
Conclusions: In the present study ibuprofen and etoricoxib significantly reduced the intensity of postoperative pain compared to placebo group. Etoricoxib showed a better preemptive analgesic activity than ibuprofen. Both drugs did not exert significant anti-inflammatory effect able to reduce swelling and trismus in comparison with placebo group.
Methods: The study design consisted of a randomized, double-blind, placebo-controlled crossover trial conducted with patients undergoing surgical removal of mandibular third molars with similar pattern of bone inclusion and surgical difficulty between right and left sides, requiring bone removal under local anesthesia. Eighteen eligible patients were allocated into three groups to receive a single dose of ibuprofen 400mg, etoricoxib 120mg, or placebo, 1-hour preoperatively. Pain intensity, use of analgesic rescue medication, swelling and trismus were evaluated. Pain intensity was recorded at 0, 2, 4, 6, 8, 10, 12, 24, 48, 72 h, 5 and 7 days following surgery. Swelling and trismus was recorded at 24, 72 h, 5 and 7 days following surgery. Parametric data was analyzed with ANOVA/Bonferroni test. The non-parametric data was analyzed with Kruskall-Wallis/Dunn or Friedman/Dunn tests. Rescue medication consumption was evaluated with Kaplan-Meyer plot. Significance level was set at p£0.05.
Results: Ibuprofen and etoricoxib reduced the pain scores in relation to placebo (p<0.0001), and etoricoxib reduced pain scores significantly in comparison with ibuprofen (p<0.05). The mean of rescue medication consumed was different between ibuprofen (1.7±2.0), etoricoxib (0.8±06), and placebo (1.0±2.7) groups over the study period (p=0.0052), and was significantly lower in the etoricoxib group in comparison with the placebo group (p<0.05). There was no statistically significant differences between groups related to swelling and trismus.
Conclusions: In the present study ibuprofen and etoricoxib significantly reduced the intensity of postoperative pain compared to placebo group. Etoricoxib showed a better preemptive analgesic activity than ibuprofen. Both drugs did not exert significant anti-inflammatory effect able to reduce swelling and trismus in comparison with placebo group.