IADR Abstract Archives
The Relation between Cardiovascular and Periodontal Disease; the PAROKRANK-study
Objectives: Objective: to test the hypothesis that periodontitis is an independent risk factor for the development of myocardial infarction.
Periodontitis is an inflammatory disease initiating an immunological defence reaction. Chronic inflammatory diseases accelerate the progress of atherosclerosis and inflammatory activation increases the risk for rupture and thrombotic occlusions leading to acute coronary syndromes. Established risk factors explain a large proportion but not all such manifestations. Whether periodontitis may be a, so far underestimated reason, for the development of cardiovascular disease is debated. Cardiovascular disease is common in patients with periodontitis. One explanation may be that the two conditions share such risk factors as diet, smoking, dysglycaemia and stress. It has been postulated, but not confirmed, that periodontitis may cause cardiovascular disease.
Methods: Methods: Case-control investigation involving 17 hospitals.
Patients (n=805) are <75 years with a first myocardial infarction. A standardized dental examination, including panorama x-ray, was performed after the index infarction together with information on disease related risk and health preserving factors. Blood lipids, plasma glucose and inflammatory markers were analysed. Saliva and plaque samples were collected.
Controls (n=805) are age, gender and area matched people without prior myocardial infarction. They were investigated in close proximity to and in the same way as the patients.
Results: Results: An interim analysis (patients n=111; controls n=93) revealed a higher OR for periodontitis expressed as dental bone loss (unadjusted OR 3.75; 95% CI: 1.86-7.55; p<0.01).
All data are collected and the analyses will be initiated in October. Subsequent analyses 1: prevalence of periodontitis; 2: similarities and discrepancies between patients and controls; 3: a logistic regression analysis on the relation between periodontitis and myocardial infarction, compensation for a large number of relevant confounders.
Conclusions: Conclusion/Importance: A support of the hypothesis will profoundly impact the attitude to treat periodontitis from the present aim to improve dental health to in addition preventing cardiovascular disease manifestations.
Periodontitis is an inflammatory disease initiating an immunological defence reaction. Chronic inflammatory diseases accelerate the progress of atherosclerosis and inflammatory activation increases the risk for rupture and thrombotic occlusions leading to acute coronary syndromes. Established risk factors explain a large proportion but not all such manifestations. Whether periodontitis may be a, so far underestimated reason, for the development of cardiovascular disease is debated. Cardiovascular disease is common in patients with periodontitis. One explanation may be that the two conditions share such risk factors as diet, smoking, dysglycaemia and stress. It has been postulated, but not confirmed, that periodontitis may cause cardiovascular disease.
Methods: Methods: Case-control investigation involving 17 hospitals.
Patients (n=805) are <75 years with a first myocardial infarction. A standardized dental examination, including panorama x-ray, was performed after the index infarction together with information on disease related risk and health preserving factors. Blood lipids, plasma glucose and inflammatory markers were analysed. Saliva and plaque samples were collected.
Controls (n=805) are age, gender and area matched people without prior myocardial infarction. They were investigated in close proximity to and in the same way as the patients.
Results: Results: An interim analysis (patients n=111; controls n=93) revealed a higher OR for periodontitis expressed as dental bone loss (unadjusted OR 3.75; 95% CI: 1.86-7.55; p<0.01).
All data are collected and the analyses will be initiated in October. Subsequent analyses 1: prevalence of periodontitis; 2: similarities and discrepancies between patients and controls; 3: a logistic regression analysis on the relation between periodontitis and myocardial infarction, compensation for a large number of relevant confounders.
Conclusions: Conclusion/Importance: A support of the hypothesis will profoundly impact the attitude to treat periodontitis from the present aim to improve dental health to in addition preventing cardiovascular disease manifestations.