Abstract Archives

IADR Abstract Archives

Zirconia Implants and Teeth: A Biological and Clinical Comparison

Objectives: The aim of this study was to compare the expression of host-derived markers in mucosal/gingival crevicular fluid (M/GCF) and clinical conditions at ceramic implants and contralateral natural teeth.
Methods: One zirconia implant (ZERAMEX®T Implant System) and one contralateral natural tooth were examined in 36 systemically healthy subjects (21 males, 15 females, mean age 58). The levels of Il-1β, Il-1RA, Il-6, Il-8, Il-17, b-FGF, G-CSF, GM-CSF, IFNɣ, MIP-1β, TNF? and VEGF were assessed in M/GCF using the Bio-Plex 200 Suspension Array System. The Plaque Index (PI), Gingival Index (GI), probing depth (PD) and Bleeding on Probing (BOP) were assessed at 6 sites around each implant or tooth. Titanium implants were also assessed when present (N=9).
Results: The zirconia implants were examined after a loading period of at least 1.2 years (average 2.2 years). Differences in the expression of all 12 biochemical markers between implants and teeth were not significant. The mean PI was significantly lower at zirconia implants compared to teeth (P=0.003), while the mean GI, PD and BOP were significantly higher (P<0.001). No significant differences were found between zirconia and titanium implants. On the contrary, a correlation was found between the levels of IL-1RA, IL-8, GM-CSF, and MIP-1β at zirconia and titanium implants as well as between the levels of G-CSF at zirconia implants and teeth (P<0.05).
Conclusions: Despite significant clinical differences of peri-implant and gingival tissues, the expression of 12 host-derived biochemical markers in the M/GCF was not.
Division: IADR/AADR/CADR General Session
Meeting: 2015 IADR/AADR/CADR General Session (Boston, Massachusetts)
Location: Boston, Massachusetts
Year: 2015
Final Presentation ID: 4383
Abstract Category|Abstract Category(s): Implantology Research
Authors
  • Hashim, Dena  ( University of Geneva , Geneva , Switzerland )
  • Cionca, Norbert  ( University of Geneva , Geneva , Switzerland )
  • Müller, Nada  ( University of Geneva , Geneva , Switzerland )
  • Cancela, José  ( University of Geneva , Geneva , Switzerland )
  • Giannopoulou, Catherine  ( University of Geneva , Geneva , Switzerland )
  • Mombelli, Andrea  ( University of Geneva , Geneva , Switzerland )
    • Support Funding Agency/Grant Number: Dentalpoint AG, Zurich, Switzerland
    Financial Interest Disclosure: Supported in part by Dentalpoint AG, Zurich, Switzerland who supplied the zirconia implants and crowns examined.
    SESSION INFORMATION
    Poster Session
    Clinical Studies, Diagnosis and Prognostic Factors
    Saturday, 03/14/2015 , 03:30PM - 04:45PM
    TABLES
    Tables uploaded as images 1 and 2 PI=Silness & Löe Plaque Index, GI=Löe & Silness Gingival Index, PD=Probing depth (in mm), BoP=Bleeding on Probing, IL=Interleukin, IL-1ra= Interleukin-1 receptor antagonist, b-FGF=Basic fibroblast growth factor, G-CSF=Granulocyte colony stimulating factor, GM-CSF=Granulocyte macrophage colony stimulating factor, IFNɣ=Interferon gamma, MIP-1β=Macrophage inflammatory protein beta, TNF?=Tumor necrosis factor alpha, VEGF= Vascular endothelial growth factor
    IMAGES
    Clinical parameters and biochemical marker levels at zirconia implants and teeth (N= 36) 
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    Clinical parameters and biochemical marker levels at zirconia and titanium implants (N= 9)  
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    A peri-apical radiograph of a zirconia implant-supported crown
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