IADR Abstract Archives
Dexmedetomidine Sedation for Tooth Extraction
Objectives: Conscious sedation for tooth extraction is commonly done in oral surgery. Although protocols and dosage of various medicines for conscious sedation for tooth extraction in outpatient are well-established, these do not include use of dexmedetomidine (DEX). The objective of the study was to establish a protocol for the use of DEX in outpatient conscious sedation and assess its acceptability.
Methods: All subjects belonging to American Society of Anesthesiologists (ASA) grade 1 or 2 were included in the study. A total of 140 patients were recruited and allocated to three groups. Forty-seven patients had their tooth removed under local anesthesia (LA). Ninety-three patients had their tooth extracted after being administered DEX intravenously (IV) (n=47; 1.0µg/kg) or intranasal (IN) (n=46; 1.5µg/kg). All procedures and dosage of DEX followed our DEX sedation protocol. Data on patient perception of pain (recorded on a visual analogue scale –VAS), patient satisfaction scores, sedation depth (using the bispectral –BIS- index), and adverse effects were collected.
Results: The patients who were administered DEX had lower VAS scores and higher satisfaction ratings compared to the LA group. There were no significant differences according to method of DEX administration. There were no notable adverse effects in any group. The BIS index for IV administration of DEX was lower than IN administration although the difference was not significant.
Conclusions: We recommend our DEX sedation protocol with IN or IV administration for tooth extraction in outpatients.
Methods: All subjects belonging to American Society of Anesthesiologists (ASA) grade 1 or 2 were included in the study. A total of 140 patients were recruited and allocated to three groups. Forty-seven patients had their tooth removed under local anesthesia (LA). Ninety-three patients had their tooth extracted after being administered DEX intravenously (IV) (n=47; 1.0µg/kg) or intranasal (IN) (n=46; 1.5µg/kg). All procedures and dosage of DEX followed our DEX sedation protocol. Data on patient perception of pain (recorded on a visual analogue scale –VAS), patient satisfaction scores, sedation depth (using the bispectral –BIS- index), and adverse effects were collected.
Results: The patients who were administered DEX had lower VAS scores and higher satisfaction ratings compared to the LA group. There were no significant differences according to method of DEX administration. There were no notable adverse effects in any group. The BIS index for IV administration of DEX was lower than IN administration although the difference was not significant.
Conclusions: We recommend our DEX sedation protocol with IN or IV administration for tooth extraction in outpatients.