Long Term Results Following Surgery with PRP, NBM and GTR

Method: Sixteen patients suffering from advanced chronic periodontitis, and each of whom displayed one advanced intrabony defect were randomly treated with either PRP+NBM+GTR (test) or NBM+GTR (control). Clinical parameters were evaluated at baseline, at 1 year and 7 years after treatment. The primary outcome variable was clinical attachment level (CAL).

Results: The test sites showed a reduction in mean probing depth (PD) from 8.5±1.4 mm to 3.0 ± 0.5 mm (p<0.001) at 1 year and to 3.6 ± 0.7 mm (p<0.001) at 7 years, respectively. In the control group mean PD was reduced from 8.5 ± 1.7 mm to 3.1 ± 1.1 mm at 1 year  (p<0.00) and to 3.4 ± 1.1 mm at 7 years. In the test group mean CAL changed from 10.4 ± 1.9 mm to 5.5 ± 0.9 mm at 1 year (p<0.001) and to 5.8 ± 1.4 mm at 7 years, respectively. In the control group mean CAL changed from 10.3 ± 2.2 mm to 5.4 ± 1.5 mm at 1 year (p<0.001) and to 6.3 ± 2.0 mm at seven years. No statistically significant differences in any of the investigated parameters were observed between the two groups at 1 and 7 years.

Conclusion: Both treatments resulted in significant PPD reductions and CAL gains. The present results have shown that the clinical improvements obtained with both treatments can over a period of 7 years.