IADR Abstract Archives

Association of Leptin and Periodontal Disease in Type II Diabetics

Background:Obesity has been identified as a influential factor for both periodontitis and diabetes mellitus (DM). Adipose tissue acts as a source of cytokines and adipokines, such as Leptin, which may play a role in these associations.

Objective: The aim of this study was to examine whether altered levels of plasma Leptin are associated with the prevalence of periodontal diseases in a cross sectional survey of people with diabetes.

Method: 370 patients with type 2 DM (T2DM) were included in this study. Basic periodontal examination (BPE) was performed and venous blood samples obtained. Plasma Leptin levels were assessed with ELISA. 

Result: A statistically significant association was found between levels of plasma Leptin and severe periodontal inflammation (BPE=4) (Kruskal-Wallis Test, p=0.005).

Conclusion: In the population examined there was an associaiton between levels of plasma Leptin and periodontal inflammation, as described by presence of BPE scores of 4 in T2DM subjects.

IADR/AMER General Session
2014 IADR/AMER General Session (Cape Town, South Africa)
Cape Town, South Africa
2014
1050
Periodontal Research - Diagnosis / Epidemiology
  • Gkranias, Nikolaos  ( UCL Eastman Dental Institute, London, , England )
  • D'aiuto, Francesco  ( UCL Eastman Dental Institute, London, , England )
  • Sadeq, Ali  ( UCL Eastman Dental Institute, London, , England )
  • Humphries, Steve  ( University College London, London, , England )
  • Hurel, Stephen  ( University College Hospital, London, , England )
  • Donos, Nikos  ( UCL Eastman Dental Institute, London, , England )
    • Poster Session
    Periodontal Disease and Systemic Diseases
    06/27/2014