Preparation and Characterization of Two New TIF₄ Nanoinclusion Complexes

Methods: To prepare the complexes the solution technique with a 1:1 (mol:mol) Cyclodextrin:TiF₄ were used. After weighing, the final aqueous solutions were achieved, and were under stirred during 12 or 72 hours. Then the samples were frozen and dried to be characterized. Macroscopic analysis to observe the possible TiF₄ oxidation by color change (grey color indicates oxidation, while white color indicates no oxidation), as well as differential exploratory calorimetry (DSC), and x-ray diffractometry tests to evaluate the nanoinclusion complexes achievement were performed.

Results: The macroscopic white color of the achieved complexes indicated the absence of oxidation of the TiF₄ complexes. With the DSC and DRX analyses it was possible to observe the change in the melting point of the complexes compared to pure cyclodextrins (CD), as well as the loss of crystallinity of the materials, respectively, indicating the formation of the nanoinclusion complexes. These characteristics were observed both samples independent of under stirring hours, however they were more pronounced for samples samples under 72 hours of stirring.

Conclusion: Therefore, the nanoinclusion complexes using Gamma-Cyclodextrin and Hydroxipropil Beta-Ccyclodextrin could be new alternatives to TiF₄ stabilization in order to prevent enamel subsurface demineralization and dental erosion.