Method: Prior to the study the clinical protocol was reviewed and approved by IRB. The study had a randomized, double-blind, parallel-group design. Subjects with two hypersensitivity teeth (tactile score: 10-50 g; air blast score: 2-3), participated in the study. Subjects were assessed using tactile and air blast indices at baseline, 2, 4 and 8 weeks after product use.
Result: A total of 81 subjects completed the study. At the baseline and 2 weeks, no significant differences in the tactile and air blast scores between the test and negative control groups were indicated. At 4 weeks the test and negative control groups showed tactile scores 25.75 and 20.85, respectively; and air blast scores 1.58 and 2.01, respectively. The test group provided significantly greater reductions in hypersensitivity than the negative control group [tactile (23.50%) and air blast (21.39%)]. At 8 weeks the test and negative control groups showed tactile scores 32.88 and 23.29, respectively; and air blast scores 1.41 and 1.95, respectively. The test group provided significantly greater reductions in hypersensitivity than the negative control group [tactile (41.18%) and air blast (27.69%)].
Conclusion: The study results demonstrated that the Colgate 360 Toothpaste provides significant reductions in hypersensitivity as compared to Colgate Cavity Protection Toothpaste after 4 and 8 weeks product use.