IADR Abstract Archives

Systemic, Acute-phase Inflammatory Burden of Periodontitis in Chronic Kidney Disease

Background: We have previously demonstrated that periodontitis associates with declining kidney function expressed as estimated glomerular filtration rate (e-GFR), and decreased vascular elasticity, in chronic kidney disease (CKD). One plausible mechanism for this association relates to the elevations in C-Reactive protein (CRP) reported in periodontitis and CKD.

Objectives: To investigate the impact of periodontitis on markers of the systemic, acute-phase response in patients with CKD.

Methods: Results are presented from an on-going longitudinal observational cohort study of patients with high-risk CKD. Patients underwent a detailed medical and dental examination including a periodontal examination (interproximal sites of all teeth).

Results: For the first 500 patients enrolled, mean age was 64 (S.D.16; Range19-92) with 60% males, 13% current smokers and 16% edentulous. Median CRP concentration was 2.9 mg/L. In multiple linear regression analyses, CRP was significantly and inversely correlated with eGFR (a marker of kidney function) (p=0.001). There was no association between various measures of periodontitis and serum concentrations of CRP.

Conclusions: High systemic CRP levels strongly correlate with declining kidney function (eGFR); however, periodontal inflammation was not associated with increased CRP levels in CKD patients.

 

 

Serum CRP (mg/L, log-transformed)

Independent Variables

β Coeff*

p-value*

β Coeff**

p-value**

β Coeff***

p-value***

eGFR

-.016

<0.001

N/A

N/A

-.012

0.001

Severe Periodontitis [Yes]

.020

0.851

-.022

0.839

-.162

0.160

Edentulism [Yes]

-.031

0.837

-.066

0.663

-.147

0.350

Mean CAL [per 1 mm]

.006

0.876

-.0119

0.770

-.039

0.350

Mean PPD [per 1mm]

.064

0.301

.0346

0.582

-.033

0.610

Cumulative PPD [per 10mm]

.010

0.427

.006

0.666

-.001

0.943

Proportion of sites BOP [per 10%]

.004

0.846

-.005

0.791

-.013

0.556

Number of teeth present

.001

0.881

.001

0.818

.003

0.633

* Adjusted for age and gender

** Adjusted for age, gender and eGFR

***Fully adjusted model

IADR/AMER General Session
2014 IADR/AMER General Session (Cape Town, South Africa)
Cape Town, South Africa
2014
65
Periodontal Research - Diagnosis / Epidemiology
  • Sharma, Praveen  ( University of Birmingham, Birmingham, , England )
  • Sidhu, Amneet  ( University of Birmingham, School of Dentistry, Birmingham, , England )
  • Rahman, Mutahir  ( University of Birmingham, School of Dentistry, Birmingham, , England )
  • Jesky, Mark  ( University Hospital Birmingham Foundation Trust, Birmingham, , England )
  • Stringer, Stephanie  ( University Hospital Birmingham Foundation Trust, Birmingham, , England )
  • Cockwell, Paul  ( University Hospital Birmingham Foundation Trust, Birmingham, N/A, England )
  • Dietrich, Thomas  ( University of Birmingham, Birmingham, , England )
  • Chapple, Iain L.c.  ( University of Birmingham, Birmingham, , England )
    • Oral Session
    Periodontal Disease and Systemic Diseases
    06/25/2014