Two modalities of periodontal regeneration techniques in aggressive periodontitis patients

Methods: 32 AgP patients, age 14-25 (mean 19.3±5.7) with multiple intra bony defects (IBD) went through a meticulous non-surgical phase followed by periodontal regeneration procedures in all IBD (at least 3 mm of the vertical component) which were randomly selected for one of the followings: periodontal regenerative procedure using bovine bone mineral (BBM, Bio-Oss®) particles as the grafted bio-material and covered by a resorbable collagen membrane (Bio-Gide®) (the GTR group), or an application of EMD on the periodontal-deprived root surface followed by an application of BBM particles soaked in EMD as the grafted bio-material (the EMD/BBM group). All surgical sites were monitored carefully by probing depth(PD), clinical attachment level(CAL), and gingival recession. Patients were assigned to a strict supportive periodontal therapy i.e. frequent periodic recalls. Pre and post-operative (at 1-year) radiographs were compared. Statistical analysis was applied using ANOVA with repeated measures.

Results: At 1-year post surgery, the GTR group (n=16; site #s – 67) showed mean PD reduction of 60.4% (from 8.40mm±1.39[SD] to 3.32mm±0.78) and CAL gain of 53.4% (from 8.49mm±1.27 to 3.95±0.52). The EMD/BBM group (n=16; site #s – 73), showed mean PD reduction of 59.6% (from 8.30±1.16 to 3.35±0.51) and CAL gain of 53.5% (from 8.49±1.27 to 3.95±0.52). Differences were statistically significant (p<0.001) between pre and post PD and CAL measurements for both groups, however, no differences between them. Post-operative radiographs disclosed a remarkable defect bone fill in both techniques

Conclusion: At 1-year observation, both surgical modalities yielded a comparative successful clinical outcome as well as radiographically in AgP patients