To study the expressions of NOD1，NF-κB and human beta-defensin 1，2，3 (hBD-1，-2，-3) in oral candidal albicans leukoplakia
Method:
The HE staining，PAS staining，silver staining，and immunohistochemical method were adopted to detect candidal albicans leukoplakia．Western blot method was used to detect and compare the expressions of NOD1 and NF-κB between the candida albicans negative and positive group in oral leukoplakia tissues．In addition，the immunohistochemical method was adopted to investigate the relationship between NOD1，NF-κB， hBD-1，-2，-3 expression and candida albicans．Then Image J software was employed to analyze the results of immunohistochemistry，and study data were compared though statistical analysis．
Result:
Our results revealed that the positive rate of candida albicans in oral leukoplakia was 47.5%．All the expressions of NOD1，NF-κB，and hBD-1，-2，-3 in oral leukoplakia tissue in the candida albicans positive group are significant weakened than that in the negative group (P<0.05)．
Conclusion:
Candida albicans infection may reduce the expression level of hBD-1，-2，-3 by inhibiting the NOD1 signaling pathway in oral leukoplakia，it may promote the development of oral leukoplakia and may be related to its greater tendency to cancer．