Method: One hundred twenty-six Syrian (golden) hamsters received 5-Fluorouracil (5-FU) followed by superficial scratching to induce OM. After that, they were divided into four groups; G1: control group; G2: treated with LED – λ630nm/80mW/3J/cm2/1,2J; G3: treated LPL - λ660nm/40mW/6J/cm²/1,2J; and G4: treated with HPL – λ808nm/1W/scanned mode/1cm from the cheek pouch mucosa. The experiment time was 10 consecutive days. The 5-FU was administered at the three first days and LED, LPL or HPL were applied between the fourth and tenth days; the clinical examination was assessed at each session in accordance to the World Health Organization guidelines.
Result: Clinical data demonstrated that animals treated with LED and LPL had a significant decrease of OM from day 7 (<0.05), while animals treated with HPL and control group had no significant difference on tissue repair.
Conclusion: These findings suggest that LED and LPL are effective in reducing 5-FU-induced OM severity, which did not take place in the HPL group.