Enhanced Remineralization of a 5000 ppm F- Dentifrice

Method: An in-vitro Remin/Demin study was conducted using bovine enamel specimens.  Products evaluated consisted of test dentifrice A containing 5000 ppm F and b-TCP; test dentifrice B containing 5000 ppm F; Clinpro^TM5000 containing 5000 ppm F and functionalized b-TCP; MI Paste Plus containing 900 ppm F and CPP-ACP; a 5000 ppm F control; and a 0 ppm F control.  The Remin/Demin cycle consisted of a 4 hr/day acid challenge in a lesion forming solution, with four, one minute treatments with dentifrice slurry.  The degree of remineralization was determined after 10 and 20 days by measuring the change in surface micro-hardness as ΔVHN.

Result: Surface microhardness results (ΔVHN) showed that test dentifrice A exhibited a statistically significant increase in micro hardness at 10 days compared to all products evaluated.  More specifically, test dentifrice A provided 49% greater remineralization compared to Clinpro^TM5000 after 10 days treatment.  At 20 days, test dentifrice A continued to demonstrate the greatest increase in surface microhardness, with results statistically significantly greater than the 0 ppm and 5000 ppm F controls and MI Paste Plus.  Results for test dentifrice A were numerically higher than test dentifrice B and Clinpro^TM5000 at 20 days, but the differences were not statistically significant.

Conclusion: Based on the in-vitro performance, it is concluded that test dentifrice A has unsurpassed remineralization efficacy versus competitor products evaluated.