Objective: To evaluate the association of Amoxycillin 20% as an alternative to the PLLA treatment of dental infections.
Method: 24 (N) polymer disks with 15mm diameter for each group F (film) and M (membrane) prepared by the methods of deposition (Casting) and electrospinning (nanofibers), respectively. All discs were stored in buffer pH 5 and aliquots were analyzed by high performance liquid chromatography (HPLC) on 8, 24, 48, 72, 96, 120, 144 and 168 hours.
Result: Group F peaked at 61% release after 144h, and group M 50% after 24 hours of storage. The variance analysis was performed using Kruskal-Wallis demonstrating differences between the groups (p = 0.03).
Conclusion: Amoxycillin may be an antibiotic having favorable and promising for use PLLA associated with the treatment and prevention of dental infections. The use of polymeric films presents greater release in relation to the membranes, but it presents a higher initial time release.