IADR Abstract Archives

New bovine bone particulate to bone healing in critical-size defects

Objective: The purpose of this study was to analyze histologically the influence of a new bovine bone particulate on bone healing in surgically created critical-size defects (CSD) in rat calvaria. 

Method: A CSD was made in each calvarium of 98 rats. They were divided into three groups: C (control) blood clot only; AB (autogenous bone) defect filled with autogenous bone; and NBB (new bovine bone): defect filled with new bovine bone (Orthogen). Animals were euthanized at 30 days. Osteoid matrix and remaining particles were evaluated histomorphometrically. Data were evaluated by statistical analysis (ANOVA and Tukey p <0.05).

Result: Group C presented a thin connective tissue in the center of the defect. Group AB presented significantly more osteiod matrix (45,72 ± 1,53mm) than Group C (0 ± 0mm) and NBB (18,96 ± 0,65mm). Lots remaining particles were observed only in Group NBB between collagen fibers. 

Conclusion: A NBB did not lead to a significant difference in bone formation in critical-size defects when compared with AB at 30 days post-operative.

IADR/AADR/CADR General Session
2013 IADR/AADR/CADR General Session (Seattle, Washington)
Seattle, Washington
2013
2642
Oral & Maxillofacial Surgery
  • Skrobot, Sérgio Henrique Merlin  ( Positivo University, Curitiba - PR, N/A, Brazil )
  • Deliberador, Tatiana  ( Positivo University, Curitiba/PR, , Brazil )
  • Trotta, Daniel  ( Positivo University, Curitiba - PR, N/A, Brazil )
  • Vieira, Juliana Sousa  ( Positivo University, Curitiba - PR, N/A, Brazil )
  • Giovanini, Allan Fernando  ( Positivo University, Curitiba - PR, N/A, Brazil )
  • Urban, Cícero De Andrade  ( Positivo University, Curitiba - PR, N/A, Brazil )
  • Zielak, João César  ( Positivo University, Curitiba/PR, , Brazil )
    • Poster Session
    Oral & Maxillofacial Surgery II
    03/22/2013