IADR Abstract Archives

Tumor-related Genes in Normal Margins Correlating with Local Recurrent OSCC

Objective: Oral squamous cell carcinoma(OSCC) is characterized by a high rate of local recurrence(LR) even the surgical margins(HNM) are “normal” by histopathologic analysis. The objective of our study was to determine the correlation of tumor-related genes detected in histological normal margins with local recurrence and disease-free survival of OSCC.

Method: We retrospectively studied LOH of D9s1747, RPS6, and D9s162 for 9p21 and TP53 on 17p13 in primary cancer and matched HNM in 71 OSCC patients.

Result: Ten out of 15 patients with local recurrence were margin positive for LOH of at least one gene under study. LOH in 9p21 and any LOH in surgical margins were significant related to the development of LR in Chi-square test(p<0.05). TP53 LOH in HNM (p<0.05), and 9p21 LOH in HNM (p<0.05) had a significant effect for LR. It was more sensitive when all markers were combined (p<0.01). Multivariate analysis revealed that any LOH in HNM is an independent prognostic factor for local relapse free survival.

Conclusion: LOH detection of tumor-related genes in histological normal surgical margins may be a useful method for local recurrence detection in OSCC patients.

Division: IADR/AADR/CADR General Session
Meeting: 2013 IADR/AADR/CADR General Session (Seattle, Washington)
Location: Seattle, Washington
Year: 2013
Final Presentation ID: 893
Abstract Category|Abstract Category(s): Oral & Maxillofacial Surgery

Authors

Wang, Xinhong ( School and Hospital of Stomatology, Guangzhou Medical Univertisity, Guangzhou, N/A, China )

Chen, Xinming ( School and hospital of stomatology, Wuhan University, Wuhan, N/A, China )

SESSION INFORMATION

Poster Session
Oral & Maxillofacial Surgery I
03/21/2013