IADR Abstract Archives

Studies of Genetic Variation in TRAV4 and Recurrent Aphthous Stomatitis

Objectives: Aphthous ulcer or canker sore or aphtous stomatitis is a type of mouth ulcer that presents as a painful open sore inside the mouth or upper throat characterized by a break in the mucous membrane. There is evidence for genetic component in recurrent aphtous stomatitis (RAS). Genes associated with the etiology of RAS likely play a critical role in initiating immune response against antigens. Our laboratory has identified TRAV4 expression in human whole saliva and we hypothesize this gene is involved in host immune responses. The goal of this study was to evaluate the possible association between TRAV4 and RAS.

Methods: RAS experience and DNA samples were obtained from the University of Pittsburgh School of Dental Medicine Dental Registry and DNA Repository (DRDR). 81 subjects who had RAS were compared to a control group of 352 subjects who did not express RAS. Four variants in TRAV4 (rs8011979, rs1997532, rs1997533, and rs7150049) were genotyped using TaqMan chemistry and PCR endpoint analysis. The chi-square test was used to test genotype and allele frequency differences with alpha of 0.05.

Results: We did not find evidence of an association between TRAV4 variants and RAS.

TRAV4 rs8011979
CC	29	125
CT	38	129
TT	11	46
c2 and p-value	0.826	0.66158
C	96	379
T	60	221
c2 and p-value	0.141	0.70774

TRAV4 rs1997532
CC	8	51
CT	27	130
TT	25	130
c2 and p-value	0.419	0.81097
C	43	232
T	77	390
c2 and p-value	0.093	0.760842

TRAV4 rs1997533
CC	10	52
CG	35	143
GG	25	133
c2 and p-value	0.959	0.61896
C	55	247
G	85	409
c2 and p-value	0.131	0.71769

TRAV4 rs7150049
AA	29	122
AG	38	133
GG	11	50
c2 and p-value	0.693	0.70699
A	96	377
G	60	233
c2 and p-value	0.004	1.0

Conclusions: Variants in TRAV4 are not associated with the occurrence of RAS. The Dental Registry and DNA Repository is supported by the University of Pittsburgh School of Dental Medicine and NIH Grant 5TL1-RR024155.

Division: IADR/AADR/CADR General Session
Meeting: 2013 IADR/AADR/CADR General Session (Seattle, Washington)
Location: Seattle, Washington
Year: 2013
Final Presentation ID: 2243
Abstract Category|Abstract Category(s): Oral Medicine & Pathology

Authors

Kim, Kenneth ( University of Pittsburgh, Pittsburgh, PA, USA )

Kim, Sojin ( University of Pittsburgh, Pittsburgh, PA, USA )

Deeley, Kathleen ( University of Pittsburgh, Pittsburgh, PA, USA )

Briseno-ruiz, Jessica ( University of Pittsburgh, Pittsburgh, PA, USA )

Vieira, Alexandre ( University of Pittsburgh, Pittsburgh, PA, USA )

SESSION INFORMATION

Poster Session
Oral Mucositis and Therapy
03/22/2013