Methods: We evaluated p300 expression in forty-eight OSCC cases by immunohistochemical examination. Data were analyzed in connection with clinicopathological factors.
Results: Whereas normal oral epithelium showed a weak nuclear expression, the OSCC cases exhibited varying staining intensities for p300, with 94% (n=45) being positive. Patients with metastatic lymph nodes (P=0.009) and advanced clinical stage (P=0.046) tended to show increased expression of p300 protein. There were no correlations between p300 staining results and other clinical factors, including patient survival (P=0.501).
Conclusions: p300 overexpression seems to correlate with a poor prognosis in OSCC patients.