Method: Sixty-five male Wistar rats were divided into three groups: control ( 30 rats, tooth movement – 100 cN), experimental (30 rats, tooth movement – 100 cN and administration of GH during 30 days) and SAIZEN® group (05 rats with administration of GH during 30 days without tooth movement). For the first two groups, the observation periods were 1,2,3,5,7 and 14 days after the tooth movement beginning. The samples were processed and qualitative and quantitative histological evaluation were performed with light microscopy.
Result: the Games-Howell multiple comparison test for heterogeneous variances verified that the experimental group presented a larger amount of osteoclasts and blood vessels on the third day (p<0,05
Conclusion:
the GH chronic use, associated with high magnitude forces, anticipated and intensified bone resorption during induced tooth movement in rats.